Abstract The limited number of targetable tumor-specific antigens and the immunosuppressive nature of the microenvironment within solid malignancies represent major barriers to the success of chimeric antigen receptor (CAR)-T cell therapies. Here. using epithelial cell adhesion molecule (EpCAM) as a model antigen. we used alanine scanning of the complementarity-determining region to f... https://danddcollectiblers.shop/product-category/easter-ornament-tree/