Activation of co-stimulatory pathways in cytotoxic T lymphocytes expressing chimeric antigen receptors (CARs) have proven to boost effector activity. tumor rejection and long-term T cell persistence. When using antigen-specific T cell receptors (TCR) instead of CARs. the lack of co-stimulatory signals hampers robust antitumoral response. https://www.nacrack.com/deal-alert-Dea-Eyewear-Jemma-deal-zone/