Anal fissure is an ischemic ulcer that occurs in anoderm and it has no obvious etiology and pathophysiology in current medicine. Anal fissure has a profound history in Persian and Persian medicine and wallflower (Erysimum cheiri (L. ) Crantz) has been a common medication in this case. https://www.roneverhart.com/William-Tuttle-Hair-White-Color-Foundation-6g/