The carboxylic acid group of quinolones was modified; so. we designed new quinolones derivatives with different antioxidants using Ligand Designer from Glide (Schrodinger LLC). The cap group and the linker were optimized through trying various aliphatic and aromatic residues. A new synthesized derivatives (IIa-Vb) were synthesized by esterification of (ciprofloxacin. https://www.ealisboa.com/great-deal-Pentair-Union-Collar-2-U11-200PS-super-offer/